Lupus Warning Signs: How to Recognize This Elusive Autoimmune Disease

Swollen Lymph Nodes: A Sign of a Flare-Up

During lupus flare-ups, lymph nodes—especially in the neck, armpits, or groin—can become swollen and tender due to increased immune activity. This can add to feelings of fatigue and general discomfort.

If you notice tender lumps in these areas, particularly alongside fever, joint pain, or fatigue, it could signal a lupus flare or infection. Persistent swelling should be checked by a doctor.